- August 19, 2015
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Are you more prone to develop Cancers because of your Diabetes?
Patients with type 1 or type 2 diabetes have a higher incidence of cancer and death from cancer, compared with the general population.
The findings highlight the importance of screening for cancer in patients with diabetes. This aids in early detection of cancers and reduce premature death.
The highest excess risks were observed for cancers of the pancreas, liver, uterus, kidney, thyroid, and gallbladder and for chronic myeloid leukemia.
Data From One of World’s Largest Diabetes Registries
The study included 953,382 registrants from the National Diabetes Service Scheme (NDSS) in Australia: 80,676 (8.5%) with type 1 diabetes and 872,706 (91.5%) with type 2 diabetes,diagnosed between the years 1997 and 2008.
This information was then linked to data from the Australian Cancer Database (ACD) to calculate standardized incidence and mortality rates of cancer overall and site-specific cancers in patients with diabetes. Cancer rates in Australia’s general population served as a comparison.
Individuals were followed from January 1, 1997 (or registration date if later) to December 31, 2008, date of death, or date of event (death or cancer occurrence).
“Given that insulin…may promote the growth of cancer cells, they wanted to explore whether type 1 patients — treated with insulin — had a higher risk for cancer compared with type 2 patients.
Excess Risk of Cancer in Both Type 1 and Type 2 Diabetes
Among females with type 1 diabetes, there were significant excess risks for cancers of the pancreas, liver, esophagus, colon and rectum, stomach, thyroid, brain, and lung, as well as ovarian and uterine cancer, and a decreased risk for melanoma, compared with the general population.
For men, a similar pattern was seen and a decreased incidence of prostate cancer was found.
Significant increase in risks for all cancers in type 2 diabetes was seen except brain, anal, esophageal cancer (in females) and testicular cancers (in men)
For type 2 diabetes,significantly increased death rates were found for cancers of the pancreas, liver, and kidney and Hodgkin’s lymphoma.
- Diabetes and cancer: a consensus report.
- Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin.